| (Published: Wed, 10 Oct 2007 21:01:48 -0500) |
| Are we "Livin" or just "Survivin"? |
| The inhibitor of apoptosis (IAP) family protects cells from self-execution by blocking the relentless caspase death cascade. IAPs bind to and inhibit activated caspases through their BIR domains. Some IAPs such as Livin also contain a RING domain that has E3 ubiquitin ligase activity and promote |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 21:00:30 -0500) |
| Transcriptional Factors And Regulators |
| All the cellular processes in living cells such as growth, development, morphogenesis and cellular differentiation are a product of gene expression programs involving complicated transcriptional regulation of several genes. This process of transcriptional regulation is tightly controlled and coordin |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:59:24 -0500) |
| Toll-Like Receptor(TLR) : Unique Antibody from Imgenex |
| Toll-like receptor (TLR) family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs are evolutionarily conserved and their congeners have been found in insects, plants, and mammals. Drosophila Toll (dToll) was the first member of the TLR fami |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:56:30 -0500) |
| Data Validation through Tissue Analysis |
| The existing body of literature using Western blot analysis has been primarily defined with data from tumor, immortal, and primary cells growing in vitro. Collectively, results obtained over decades have been integral to the dogma that up- and down-regulation of proteins can be leveraged as Biomarke |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:53:26 -0500) |
| Improved RNA interference kits launched by Imgenex |
| RNA interference (RNAi) is the process of mRNA degradation that is induced by double-stranded RNA in a sequence-specific manner. RNAi has been observed in all eukaryotes, from yeast to mammals. The RNAi pathway is thought to be an ancient mechanism for protecting the host and its genome against viru |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:52:17 -0500) |
| Regulatory T Cells (Treg) |
| Early development and differentiation of nascent T cells that migrate from bone marrow to become mature, naïve T cells, which are capable of responding to antigen takes place inside the thymus. Around 1010 TCR (T cell receptor) variations are generated in developing T lymphocyte clones through a ran |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:48:51 -0500) |
| NF-kB Activation: Elucidating Upstream Events |
| The classical pathway for activation of NF-kB, a key transcriptional regulator of the immune system, is controlled by the IKK complex. Activated IKK phosphorylates IkB which is ubiquitinated and rapidly degraded, allowing NF-kB to translocate from the cytoplasm to the nucleus where it activates gen |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:47:07 -0500) |
| GPCRs: Exploring New Paradigms |
| As one of the largest and most diverse protein families in nature, the G-protein coupled receptor (GPCR) superfamily play important roles in a variety of biological and pathological processes such as development and pro |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:45:38 -0500) |
| Fundamental Immunology, Basic Immunology and Allergy Immunology |
| Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. The immune system is the body's defense against infectious organisms and other invaders. Through a series of steps called the immune response, the immune system attacks orga |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:41:40 -0500) |
| New FOXP3Δ2 (Exon 2 Deleted) Specific Antibody |
| FOXP3 is a master regulator of immune homeostasis expressed specifically in CD4+ CD25+ T regulatory cells controlling their growth, development and function. FOXP3 significance in the normal development of Tregs is better elucidated with the fact that mutated FOXP3 results in a rare and fatal early |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:40:04 -0500) |
| GPR83: A Novel Treg Expressed Cell Surface Marker |
| As research continues to unravel the molecular basis of regulatory T cells (Treg), FOXP3 has emerged as a key player in orchestrating development and function of natural Treg. Two recent publications identified GPR83 as specifically upregulated in fresh and activated CD4+ CD25+ Treg cells. Both grou |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:38:42 -0500) |
| Epigenetic and Signal Transduction Reagents |
| IMGENEX offers over 90 Chromatin, DNA Methylation & Repair, and DNA Fragmentation-related antibodies, many of which have been cited in numerous peer-reviewed journals. These antibodies have been used to study transcriptional silencing, identify DNA-protein interactions, and characterize the sequenc |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:36:07 -0500) |
| QuikChIP Chromatin Immunoprecipitation Kits |
| IMGENEX QuikChIP Certified Antibodies The Basics...
The principle of the ChIP assay is simple: selective enrichment of a chromatin fraction containing a specific target. However, the process can be technically challenging. It is with these challenges in mind that IMGENEX developed the QuikChIP Ki |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:30:57 -0500) |
| ATM (Ataxia Telangiectasia Mutated) Antibodies from Imgenex |
| ATM, the gene product mutated in the cancer susceptibility syndrome ataxia–telangiectasia, is related to proteins involved in DNA repair and cell-cycle control. It encodes a nuclear 350 kDa phosphoprotein containing a carboxy terminus phosphatidylinositol 3-kinase (Pl-3 kinase) catalytic domain shar |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:22:38 -0500) |
| Apoptosis Programmed Cell Death |
| Coined in the 1960's,apoptosis is derived from the Greek word apopiptein which means to fall off from. Apoptosis can be induced by a number of stimuli including UV damage, irradiation, drug treatment, or tumor necrosis factor. Once induced, apoptosis can, in turn, act through a number of different c |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:18:50 -0500) |
| Akt Family: Antibodies from Imgenex |
| Akt family of serine/threonine-directed kinases regulates a diverse array of biological processes, including cellular survival, proliferation, glucose homeostasis, and vascular tone and are important molecules in mammalian cellular signaling. The three widely expressed isoforms of PKB (PKB , PKBß an |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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| (Published: Wed, 10 Oct 2007 20:15:24 -0500) |
| Actin Antibody Available in Imgenex now |
| Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is the monomeric subunit of microfilaments, one of the three major components of the cytoskeleton, and of thin filaments which are part of the contractile apparatus in muscle cells. |
| Author: Stephen Jones |
| Directory: Disease & Illness - Cancer |
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